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University of Würzburg - Theodor-Boveri-Institute - Cell and Developmental Biology
The research of my group focuses on the molecular control of cardiac differentiation and the elucidation of mechanisms regulating heart morphogenesis.
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Profile
| The research of my group focuses on the molecular control of cardiac differentiation and the elucidation of mechanisms regulating heart morphogenesis. We are using the chick embryo for various manipulations involving signaling molecules and transcription factors important for heart field formation, left-right asymmetry, and coronary artery development. In addition we are studying a novel family of membrane proteins with an abundant expression in heart and skeletal muscle. We have generated kockout mutations for two of the three members present in the mammalian genome and are currently involved in generating a mouse mutant that lack the entire Popeye gene family. In addition we perform experiments to characterize the function of this genes at the cellular and protein level. |
Technologies / Research Focus
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specification of cardiac mesoderm in the chick embryo
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Nkx homeobox genes
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left-right specific morphogenesis
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coronary artery development
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functional characterisation of the "Popeye" gene family
- transcriptional control of the "Popeye" gene family
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Info
 | | A) Mouse embryo. B) Cellular localization of Popeye protein. C) Meolecular model of Popeye protein. |  |
Services
- advice
- expertise
- common R&D projects
- diploma theses
- PhD theses
Cooperation interest
- Molecular basis of cardiac development
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Contact University of Würzburg
Theodor-Boveri-Institute
Cell and Developmental Biology
Am Hubland
D-97074 Würzburg Contact: Work Group Leader Telephone:
+49(0)931 - 888 42 59 Fax:
+49(0)931 - 888 42 52 |
